The team followed this with experiments on mice engineered to have the same genetic defect. With a regular diet, the pregnant mice had either miscarriages or pups with a range of severe birth defects. However, once vitamin B3 was introduced into the diet of the pregnant mice, the miscarriages and birth defects ended, and all the pups were born healthy.
Lisa Waddell, deputy medical officer at the March of Dimes, which funds research and programs to end premature birth, birth defects and infant mortality. Waddell, who was not involved in the study, warned that additional research in humans is needed before advising pregnant women to take B3 above and beyond the current US recommendation of 18 milligrams a day.
Sarah Stock, senior clinical lecturer at the University of Edinburgh who also was not involved in the study, said it is "exciting" in that it increases our understanding of birth defects. More research is needed in humans, she agreed, and on what dose would be safe for women.
David Amor, a clinical geneticist and professor at the University of Melbourne, said "there is no reason to believe that dietary niacin deficiency is a major cause of birth defects in the general population. Amor, who was not involved in the research, noted that the genetic condition studied by Dunwoodie and her colleagues is "likely to be very rare.
Overweight pregnancy increases risk of birth defects, study says. Michael Fenech of the Commonwealth Scientific and Industrial Research Organization, a government agency for scientific research in Australia, said the new research is "an important discovery.
Niacin Overview Updated: April 26, How was your experience with Nicotinic Acid? First, a little about yourself Male Female. What tips would you provide a friend before taking Nicotinic Acid? Choose one. Back Next. How well did Nicotinic Acid work for you? Did you experience many side effects while taking this drug? How likely would you be to recommend Nicotinic Acid to a friend?
Back Submit. Niacin Cautionary Labels Back to Top. Uses of Niacin Back to Top. Niacin Brand Names Back to Top. Niacin Drug Class Back to Top. Niacin is part of the drug class: Nicotinic acid and derivatives. Side Effects of Niacin Back to Top. Serious side effects have been reported with niacin. See the "Niacin Precautions" section.
Common side effects of niacin include: flushing rash diarrhea nausea vomiting increased cough Flushing is the most common side effect of niacin. Symptoms of flushing may include any or all of the following: warmth redness itching tingling of the skin Flushing does not always happen.
If you wake up at night because of flushing, get up slowly, especially if you: feel dizzy or faint take blood pressure medicines To lower your chance of flushing: Ask your doctor if you can take aspirin to help lower the flushing side effect from niacin. You can take aspirin up to the recommended dose of mg about 30 minutes before you take niacin to help lower the flushing side effect. Do not drink hot beverages including coffee , alcohol, or eat spicy foods around the time you take niacin.
Take niacin with a low-fat snack to lessen upset stomach. Tell your doctor if you have any side effect that bothers you or does not go away. Niacin Interactions Back to Top. Especially tell your doctor if you take: supplements or medications containing niacin or nicotinamide other medicines to lower cholesterol or triglycerides aspirin insulin or medications for diabetes blood pressure medicines anticoagulants "blood thinners" such as warfarin Coumadin, Jantoven bile acid-binding resins such as colestipol Colestid or cholestyramine Questran large amounts of alcohol This is not a complete list of niacin drug interactions.
Niacin Precautions Back to Top. Serious side effects have been reported with niacin, including: dizziness feeling faint hast heartbeat nausea vomiting extreme tiredness dark colored urine light colored stools unusual bleeding or bruising loss of appetite pain in the upper right part of the stomach yellowing of the skin or eyes flu-like symptoms difficulty breathing or swallowing swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs hoarseness unexplained muscle pain, tenderness, or weakness Niacin can cause dizziness and blurred vision.
Do not take niacin if you: are allergic to niacin or to any of its ingredients have liver problems have a stomach ulcer have bleeding problems.
Niacin Food Interactions Back to Top. Inform MD Back to Top. Especially tell your doctor if you: are allergic to niacin or to any of its ingredients. Tell your doctor if your blood sugar levels change after you take niacin. Niacin and Pregnancy Back to Top. Tell your doctor if you are pregnant or plan to become pregnant. Niacin and Lactation Back to Top. Please try again. Something went wrong on our side, please try again.
Show references Shi H, et al. NAD deficiency, congenital malformations and niacin supplementation. New England Journal of Medicine. Schandelmaier S, et al. Niacin for primary and secondary prevention of cardiovascular events.
Cochrane Database of Systematic Reviews. Accessed Aug. Micromedex 2. Niacin B3; nicotinic acid oral. Melmed S, et al. Disorders of lipid metabolism. In: Williams Textbook of Endocrinology. Philadelphia, Pa. Pazirandeh S. Overview of water-soluble vitamins. Natural Medicines. Mayo Clinic Press Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. ART Home Niacin. Legal Conditions and Terms Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below.
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